Episodes

  • Dr. Martha Gulati, MD: Women's Heart Disease, Female-Specific Risk Factors, and What Medicine Gets Wrong About Cardiovascular Health

    Dr. Martha Gulati, MD: Women's Heart Disease, Female-Specific Risk Factors, and What Medicine Gets Wrong About Cardiovascular Health
    Jun 11 2026
    Heart disease is not only a man's disease. It is the number one killer of women, responsible for ten times more deaths than breast cancer. And yet most women have never had a real conversation about their cardiovascular risk, because the medical system was not built to catch it in them.Dr. Martha Gulati is the Director of Preventive Cardiology and Associate Director of the Barbra Streisand Women's Heart Center at Cedars-Sinai, Director of the Davis Women's Heart Center at Houston Methodist, and author of Saving Women's Hearts. Her own quote has become one of the most cited lines in women's cardiology: "Heart disease is the number one killer of women, but lack of awareness is a close second."This conversation goes into how the female heart develops disease differently, why women's symptoms get dismissed even when they use the words chest pain, and the pregnancy complications, hormonal history, and inflammatory conditions that quietly raise cardiovascular risk for decades before anything shows up on a standard panel.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.⁠https://kayla-barnes-lentz.circle.so/female-longevity-community⁠If you’re already paying attention to food, sleep, and overall health, cleaning products are another place where exposure adds up quickly. Branch Basics is a simple way to clean your home with fewer unnecessary ingredients and less clutter under the sink.⁠https://branchbasics.com/KAYLA15⁠ What we cover:How women's heart attack symptoms differ from men and why they still get dismissed in the ERWhy women wait longer, receive fewer tests, and are less likely to see a cardiologist when they arrive with chest painThe labs every woman should ask for, including LP(a), high-sensitivity CRP, and ApoB, with specific reference rangesWhy women get more cardiovascular benefit per minute of exercise than men, and what the exercise prescription actually looks likeMediterranean diet, hidden salt, sleep, and the lifestyle foundations that move the needleConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comConnect with Dr. Marth Gulati:Website: https://www.drmarthagulati.com/Instagram: https://www.instagram.com/drmarthagulatiLinkedIn: https://www.linkedin.com/in/martha-gulati-9b410496/Her Book (Saving Women’s Hearts): https://www.drmarthagulati.com/general-2 #WomensHealth #HeartDisease #WomensHeartHealth #Cardiology #FemaleLongevity #HeartHealth #LongevityPodcast #PreventiveCardiology #HeartDiseaseInWomen #WomensCardiology #LongevityOptimization #KaylaBarnesLentz #HeartHealthForWomen #FemaleHealth #MarthаGulati
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    1 hr and 1 min
  • Dr. Jolene Brighten, ND - Endometriosis, Adenomyosis, PMDD, PMOS and Postpartum Hormones

    Dr. Jolene Brighten, ND - Endometriosis, Adenomyosis, PMDD, PMOS and Postpartum Hormones
    Jun 4 2026
    Women are often told that painful periods, irregular cycles, bloating, mood changes, fatigue, brain fog, postpartum symptoms, and hormonal shifts are “normal.”But common does not mean something should be ignored.In this episode, Dr. Jolene Brighten, ND joins me for a practical deep dive into female-specific conditions that are too often missed, minimized, or treated in isolation, including endometriosis, adenomyosis, PMDD, PCOS/PMOS, fibroids, postpartum thyroid changes, and the gut-hormone connection.Dr. Brighten explains why endometriosis is not just a reproductive condition, how adenomyosis differs from endometriosis, why PMDD is not simply “bad PMS,” how histamine may play a role in cyclical symptoms, and why PCOS is now being reframed as a broader metabolic and endocrine condition.Join the most comprehensive female-specific community for health and longevity optimization. After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/female-longevity-communityThis episode is sponsored by Zen Basil. Their certified edible basil seeds are designed for human nutrition, deliver 15g of fiber per serving, and are batch-tested for glyphosate and over 400 pesticides. Use the code KAYLA20 for 20% off.https://zenbasil.com/shopzenbasil/zenbasilseedbagIn this conversation:-Why endometriosis is a full-body inflammatory condition-The difference between endometriosis and adenomyosis-The three types of endometriosis and why imaging matters-Why painful periods, ovulation pain, gut symptoms, and fatigue deserve investigation-The connection between histamine, estrogen, progesterone, and cyclical symptoms-Why PCOS is now being reframed as PMOS-Insulin resistance, GLP-1s, estrogen metabolism, and inflammationConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comConnect with Dr Jolene:Website: https://drbrighten.com/Instagram: https://www.instagram.com/drjolenebrightenYouTube: https://www.youtube.com/@DrJoleneBrighten Order Her New Book: https://drbrighten.com/adhd-in-women/
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    1 hr and 48 mins
  • Dr. Izabella Wentz: IBS Root Causes, Leaky Gut, Autoimmunity, and How To Start Healing Your Gut

    Dr. Izabella Wentz: IBS Root Causes, Leaky Gut, Autoimmunity, and How To Start Healing Your Gut
    May 28 2026
    Less than 25% of people with IBS get real relief from conventional medicine. That number tells you everything about how the current approach is failing.Most people with IBS have been told it is stress, told to take medication, and sent home. But irritable bowel syndrome is not one condition, it is a label applied to a cluster of symptoms that can have 20 to 40 completely different root causes. And left unaddressed, it is one of the most reliable predictors of autoimmune disease down the line.In this episode I sit down with Dr. Izabella Wentz, clinical pharmacist, functional medicine expert, and NYT bestselling author known as the Thyroid Pharmacist. After her own IBS diagnosis in pharmacy school preceded her Hashimoto's diagnosis by six years, she has spent over a decade connecting the dots between gut dysfunction and autoimmunity for hundreds of thousands of people.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberIf you’re already paying attention to food, sleep, and overall health, cleaning products are another place where exposure adds up quickly. Branch Basics is a simple way to clean your home with fewer unnecessary ingredients and less clutter under the sink.https://branchbasics.com/KAYLA15Code: KAYLA15We explore:-Why IBS precedes autoimmune disease by 5 to 10 years-The three conditions that must all be present for autoimmunity to manifest-Why women are twice as likely to have IBS during their reproductive years and the specific hormonal and lifestyle drivers-The functional medicine testing approach versus what most GI doctors actually look at-Why gluten particles cross-react with thyroid tissue and what that means for anyone with Hashimoto's-How to actually get mold out of the body and why it disrupts the gut microbiome so severely-The gut healing protocol that got Dr. Izabella's husband into remission from ulcerative colitis in two monthsConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr Izabella:Instagram: https://www.instagram.com/izabellawentzpharmd/Website: https://thyroidpharmacist.com/Youtube: https://www.youtube.com/user/ThyroidPharmacist#guthealth #IBS #irritablebowelsyndrome #leakygut #autoimmune #hashimotos #thyroidhealth #womenshealth #femalelongevity #longevity #gutmicrobiome #functionalhealth #functionalmedicine #rootcause #parasites #SIBO #foodsensitivities #guthealing #healthoptimization #preventivemedicine
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    56 mins
  • Dr. Scott Sherr, MD: Why Stress Blocks Healing: Mitochondria, Immune Aging, Hyperbaric Oxygen, and Methylene Blue

    Dr. Scott Sherr, MD: Why Stress Blocks Healing: Mitochondria, Immune Aging, Hyperbaric Oxygen, and Methylene Blue
    May 21 2026
    There is a state where the body gets locked in sympathetic activation and mitochondrial dysfunction at the same time and no matter what supplements you take, no matter what protocols you run, nothing actually works. Dr. Scott Sherr calls it the sympathetic spiral of doom, and in this episode we break down exactly what it is, why so many people are stuck in it without knowing it, and the right sequence to actually get out.Dr. Scott is a board certified internal medicine physician, certified in hyperbaric oxygen therapy and health optimization medicine, and the chief medical officer of One Base Health, the company behind the hyperbaric chamber you see in every episode. He advises me personally on my hyperbaric protocols, including the ovarian longevity protocol I have been running, and this conversation goes deep into the science behind why that protocol makes sense and what we are actually trying to achieve.This episode is sponsored by Zen Basil. Their certified edible basil seeds are designed for human nutrition, deliver 15g of fiber per serving, and are batch-tested for glyphosate and over 400 pesticides. Use the code KAYLA20 for 20% off.⁠https://zenbasil.com/shopzenbasil/zenbasilseedbag⁠Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/female-longevity-communityExplore Troscriptions’ mitochondrial, immune, and nervous system support products. Use code KAYLA10 at checkout for 10% off.https://troscriptions.comIn This Conversation:- Why Autoimmunity Risk Rises In Women During Perimenopause - Why The Body Can’t Heal When Stuck In Stress Mode- How Chronic Stress And Social Media Can Reduce Recovery Capacity- What Methylene Blue Does- Why The Gaba System Matters- When Hyperbaric Therapy HelpsConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Scott Sherr and his work:Websites:drscottsherr.comhomehope.orgonebasehealth.comTroscriptions.comInstagram:https://www.instagram.com/troscriptions/https://www.instagram.com/drscottsherr/https://www.instagram.com/onebasehealth/https://www.instagram.com/homehopeorg/Youtube:https://www.youtube.com/@troscriptionshttps://www.youtube.com/@drscottsherrLinkedIn:https://www.linkedin.com/in/drsherr/https://www.linkedin.com/company/troscriptions/https://www.linkedin.com/company/onebasehealth/
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    1 hr and 32 mins
  • Dr. Poonam Desai: The 5 Labs Women Need, Heart Disease Risk, Microplastics, and Perimenopause

    Dr. Poonam Desai: The 5 Labs Women Need, Heart Disease Risk, Microplastics, and Perimenopause
    May 14 2026
    Most women have had bloodwork done. What most women haven't had is the right bloodwork. In this episode, Dr. Poonam Desai, double board certified in lifestyle and emergency medicine, NAM certified in menopause care, and founder of Longevity Place and Her Longevity, breaks down the five labs she runs on every female patient, the optimal values most physicians aren't targeting, and why the standard panel tells you almost nothing about long-term cardiovascular risk, metabolic health, or inflammation. This is one of the most practical longevity conversations I've had for women who want to know where they actually stand.We also go deep on the three female life phases medicine consistently underserves, how women's cardiac symptoms are still being dismissed in clinical settings, and what a real foundational protocol looks like before any advanced intervention enters the picture. The perimenopause section is worth your full attention, what is shifting hormonally and metabolically, why those symptoms should not be pushed through, and why the window for acting is earlier than most women are told.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberIf you’re already paying attention to food, sleep, and overall health, cleaning products are another place where exposure adds up quickly. Branch Basics is a simple way to clean your home with fewer unnecessary ingredients and less clutter under the sink.https://branchbasics.com/KAYLA15Code: KAYLA15In This Conversation:-Why women need a different longevity lens than men-The cardiovascular markers Dr. Desai wants women tracking early-Why blood pressure, resting heart rate, HRV, and snoring matter more than people think-How to use bowel movements as a simple gut-health signal-Why she starts with fiber before protein-The overlooked role of toxins, plastics, and hormone disruptors-What women should not ignore in perimenopause-Why knowing your numbers early changes everythingConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Poonam Desai:Instagram: https://www.instagram.com/drpoonamdesai/LinkedIn: https://www.linkedin.com/in/dr-poonam-desai/Website: https://www.drpoonamdesai.com/Her Substack: https://drpoonamdesai.substack.com/
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    1 hr and 3 mins
  • Prof. Belinda Beck, PhD: Bone Health: Building Strong Bones, Preventing Age-Related Loss, And Reversing Osteoporosis With Evidence-Based Exercise

    Prof. Belinda Beck, PhD: Bone Health: Building Strong Bones, Preventing Age-Related Loss, And Reversing Osteoporosis With Evidence-Based Exercise
    May 7 2026
    Most women are not thinking about their bones until a fracture happens or a scan comes back alarmingly. By then, the window for the most impactful intervention has often been narrowing for decades. Bone density peaks around age 18, not 30 as widely believed and the slow decline that follows is largely silent until it isn't.Professor Belinda Beck, PhD has spent more than two decades studying exactly what it takes to stop and reverse that decline. She is a professor at Griffith University, founder of the Bloom Clinic in Brisbane, and the principal investigator behind the LIFTMORE trials, a body of research that changed the scientific consensus on what is actually possible for women with osteoporosis and osteopenia. Her findings showed that heavy resistance and impact training twice weekly can safely grow bone mineral density in the spine and hip, even in women already diagnosed with very low bone mass and prior osteoporotic fractures. This was not what the medical establishment expected. And it fundamentally changed how serious practitioners now think about bone.This episode is sponsored by Zen Basil. Their certified edible basil seeds are designed for human nutrition, deliver 15g of fiber per serving, and are batch-tested for glyphosate and over 400 pesticides. Use the code KAYLA20 for 20% off.https://zenbasil.com/shopzenbasil/zenbasilseedbagJoin the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/female-longevity-communityIn this conversation we explore:- Why bone density peaks at 18 and what that means for every stage of life after- The LIFTMORE trial: what they did, who the participants were, and what the results showed- Why heavy lifting is the key variable and why conventional low-intensity exercise recommendations failed- What estrogen does to bone and why menopause causes such rapid loss- The truth about weighted vests, calcium supplements, and other popular bone health interventions- What GLP-1 drugs are doing to bone and muscle and what to do about it- Age-specific recommendations for women in their 20s to 30s, 40s to 50s, and postmenopauseConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn More About Prof. Belinda Beck and Her Work:LinkedIn: https://www.linkedin.com/company/the-bone-clinic/ ONERO® locations map: https://onero.academy/locations/ONERO® Academy: https://onero.academy/The Bone Clinic website: https://theboneclinic.com.au/#bonehealth #bonedensity #osteoporosis #osteopenia #femalelongevity #womenshealth #heavylifting #strengthtraining #weighttraining #perimenopause #menopause #longevity #DEXA #LIFTMOREtrial #bonelosss #resistancetraining #healthoptimization #womenslongevity #exercisescience #preventivemedicine
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    1 hr and 11 mins
  • Dr. Dawn Mussallem, DO: Cancer Prevention, Early Detection, Exercise, Metabolic Health and Breast Cancer Screening

    Dr. Dawn Mussallem, DO: Cancer Prevention, Early Detection, Exercise, Metabolic Health and Breast Cancer Screening
    Apr 30 2026
    In this episode, I’m joined by Dr. Dawn Mussallem, DO, an integrative oncologist, lifestyle medicine specialist, cancer survivor, heart transplant recipient, and the newly appointed Chief Medical Officer of Fountain Life.We talk about why cancer rates are rising, what we actually know about prevention, and why early detection matters so much when it comes to long-term outcomes. We also discuss the role of exercise, sleep, fiber, metabolic health, toxins, alcohol, gut health, screening tools, mammograms, full-body MRI, liquid biopsies, and why the basics still matter more than most people want to admit.Dr. Dawn also shares her extraordinary personal story: She is a stage 4 cancer survivor who went through chemotherapy and a bone marrow transplant at 26, developed cardiac toxicity from treatment 18 years later, received a heart transplant, and became the first person in the world to run a marathon within a year of receiving a new heart. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberIf you’re already paying attention to protein, blood sugar, and longevity nutrition, fiber is one of the biggest gaps to fix. Zen Basil makes it simple to add more fiber, minerals, and prebiotic support into your routine with certified edible basil seeds that are tested for glyphosate and over 400 pesticides.Use the code KAYLA20 for 20% off.https://zenbasil.com/shopzenbasil/zenbasilseedbagIn this episode:- Why cancer is rising in younger people- The lifestyle factors linked to cancer prevention- Why exercise matters during and after cancer treatment- The role of sleep, insulin, and metabolic health- Fiber, gut health, and the microbiome- Mammograms, breast MRI, full-body MRI, and liquid biopsies- Soy, breast cancer myths, and plant protei- Hormone therapy, breast cancer risk, and screening- Why connection and purpose matter for longevityConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Dawn Mussallem:Instagram: https://www.instagram.com/drdawnmussallem/LinkedIn: https://www.linkedin.com/in/dawn-mussallem-do-dipablm-2b360b57/Website: https://www.fountainlife.com/#cancerprevention #breastcancer #femalelongevity #womenshealth #longevity #integrativeoncology #cancersurvivorship #earlydetection #breastcancerawareness #hormonehealth #metabolichealth #exerciseandcancer #soyandcancer #perimenopause #menopause #cancerresearch #preventivemedicine #healthoptimization #womenslongevity #fountainlife
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    1 hr and 25 mins
  • Dr. Brian Kennedy, PhD: The Real Science of Longevity: mTOR, Rapamycin & How to Measure Biological Age

    Dr. Brian Kennedy, PhD: The Real Science of Longevity: mTOR, Rapamycin & How to Measure Biological Age
    Apr 23 2026
    Brian Kennedy is one of the world’s leading researchers studying the biology of aging.In this conversation, we break down what longevity science actually shows about extending healthy lifespan and the everyday habits that appear to influence how we age.Dr. Brian shares insights from decades of aging research, explaining how scientists study longevity, how interventions like rapamycin and biological age testing are evaluated, and how lifestyle factors such as exercise, nutrition, fasting, and sleep continue to shape the foundation of long-term health.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-member5 key longevity habits discussed in this episode:- Exercise and physical activity- Nutrition and metabolic health- Energy balance and fasting- Sleep and recovery- Longevity interventions and emerging therapiesTogether, these factors form the foundation researchers believe will have the greatest impact on healthspan as longevity science continues to evolve.Connect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Brian Kennedy:LinkedIn: https://www.linkedin.com/in/brian-kennedy-69777318/Website: https://medicine.nus.edu.sg/trp/healthy-longevity/
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    2 hrs and 34 mins