What does it take to challenge decades of conventional medical practice?

In this episode of Entrepreneur Rx, host John Shufeldt sits down with Dom Messerli, founder and CEO of Lenoss Medical, to discuss his journey from medical device executive to entrepreneur. Dom shares how listening to surgeons led him to develop a biological alternative to traditional bone cement used in spinal fracture procedures, the challenges of building a medical device company, and the lessons learned scaling a healthcare innovation from concept to commercialization.

The conversation explores entrepreneurship, risk-taking, leadership, company culture, fundraising, and what it takes to bring meaningful innovation to patients and physicians alike.

About Dom Messerli: Dom Messerli is the founder and CEO of Lenoss Medical. With decades of experience in the medical device industry, including leadership roles at Synthes, Dom has dedicated his career to developing innovative solutions that improve patient outcomes. Drawing on years of collaboration with spine surgeons, he founded Lenoss Medical to address longstanding challenges in the treatment of vertebral compression fractures through biologic, patient-focused technologies.

About Lenoss Medical: Lenoss Medical is a medical technology company focused on advancing the treatment of vertebral compression fractures. Its flagship product, OsteoPearl®, is a biologic implant designed to provide an alternative to traditional bone cement used in spinal procedures. By leveraging natural bone-derived materials, Lenoss aims to improve patient outcomes while reducing risks associated with conventional treatment approaches.

About Xcellerant Ventures: Xcellerant Ventures is a venture capital firm that invests in innovative companies across healthcare, technology, defense, and other emerging industries. Through multiple funds and investment vehicles, including the Jetstream Venture Fund, the firm partners with visionary founders, provides strategic guidance, and helps connect investors with opportunities in the private markets. Its portfolio includes companies developing solutions that have the potential to transform industries and improve lives.

About Jetstream Venture Fund: Jetstream Venture Fund is an interval fund managed by Xcellerant Ventures and Sweater Industries LLC, that seeks to provide investors access to early-stage, high-growth companies with flexible terms, lower minimums ($5,000 minimum investment), and no carried interest. Jetstream is one of the first funds of its kind, bringing venture-style investing opportunities to a wider professional audience. Back-end administration is provided by Sweater Ventures a ground-breaking turnkey fund management company.Disclosure for Jetstream: Investors should carefully consider the investment objectives, risks, charges, and expenses of the Fund before investing. The prospectus contains this and other information about the Fund and can be obtained by emailing jetstream@sweaterfunds.com or by visiting the Fund's website. Please read the prospectus carefully before investing.

In this episode of Entrepreneur Rx, John sits down with Allisa Song, Co-Founder and CEO of MU Medical. Allisa shares the story behind developing NanoDropper, a device designed to reduce medication waste and improve patient adherence, as well as her entrepreneurial journey. They discuss the realities of building healthcare companies, navigating the challenges of entrepreneurship, and bringing innovative solutions to patients and providers. Whether you're a founder, healthcare professional, or aspiring entrepreneur, this conversation offers valuable insights on innovation, leadership, and creating meaningful impact in healthcare.

About Allisa: Allisa Song, MD, is the co-founder and CEO of Mu Medical, the company behind NanoDropper®, an innovative adapter that reduces the size of eye drops to help patients improve medication adherence, reduce waste, and lower treatment costs. She founded the company while attending the Mayo Clinic Alix School of Medicine after identifying a widespread challenge facing glaucoma patients. Today, she leads Mu Medical's mission to improve ophthalmic drug delivery through innovative technologies that enhance patient outcomes and advance eye care.

About Mu Medical: Mu Medical is an ophthalmic medical technology company dedicated to improving how eye medications are delivered. Its flagship product, NanoDropper®, helps patients reduce medication waste, extend the life of prescription eye drops, and improve adherence to treatment. Today, the company is expanding beyond NanoDropper to develop innovative drug delivery and packaging solutions aimed at transforming the future of ophthalmology.

About Xcellerant Ventures: Xcellerant Ventures is a venture capital firm that invests in innovative companies across healthcare, technology, defense, and other emerging industries. Through multiple funds and investment vehicles, including the Jetstream Venture Fund, the firm partners with visionary founders, provides strategic guidance, and helps connect investors with opportunities in the private markets. Its portfolio includes companies developing solutions that have the potential to transform industries and improve lives.

About Jetstream Venture Fund: Jetstream Venture Fund is an interval fund managed by Xcellerant Ventures and Sweater Industries LLC, that seeks to provide investors access to early-stage, high-growth companies with flexible terms, lower minimums ($5,000 minimum investment), and no carried interest. Jetstream is one of the first funds of its kind, bringing venture-style investing opportunities to a wider professional audience. Back-end administration is provided by Sweater Ventures a ground-breaking turnkey fund management company.Disclosure for Jetstream: Investors should carefully consider the investment objectives, risks, charges, and expenses of the Fund before investing. The prospectus contains this and other information about the Fund and can be obtained by emailing ⁠jetstream@sweaterfunds.com⁠ or by visiting the ⁠Fund's website⁠. Please read the prospectus carefully before investing.

For episode 85 of Entrepreneur Rx, John welcomes Courtney Williams, co-founder and CEO of Emagine Solutions Technology. Emagine is tackling the U.S. maternal health crisis with remote patient monitoring. The podcast starts off with Courtney touching on her diverse background and then she moves to how her sister’s high-risk pregnancy inspired her to get into healthcare entrepreneurship. This experience opened her eyes to the dangers of pregnancy and the lack of access to safe healthcare for pregnant women. 

Inspired to make a change, Courtney and her team developed a handheld ultrasound device called VistaScan that is FDA cleared and aimed at low-resource settings. However, they soon realized that the lack of access to healthcare is not just a problem in developing countries but also in their own community. This led them to where Emagine Solutions Technology is today - a maternal health focus. Shortly after, Courtney and her team developed The Journey Platform which is geared towards better connecting providers and patients.

Courtney then moves on to discussing challenges in the femtech industry and funding for female entrepreneurs. She wraps up the podcast by sharing her biggest challenge she has faced as an entrepreneur, Emagine’s potential exit in the future and her hopes for the future of Emagine. Courtney's unwavering commitment to leveraging technology to enhance maternal health outcomes is a testament to her visionary leadership and dedication to making a meaningful impact.