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The Saving Dose

The Saving Dose

By: John Hsu Kendra Allen William Pedranti
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The podcast for those building the future of healthcare. A clinician, a healthcare attorney, and a behavioral health executive on what's actually working in addiction, adherence, and the capital reshaping both.


75% of patients do not take medications as prescribed. 125,000 Americans die from it every year. $528 billion in preventable costs trace directly to a gap the healthcare system has known about for decades and never closed: what happens after the prescription is written.

The Saving Dose is a podcast about that gap, the space between the clinic visit and the outcome, between the evidence-based treatment and the patient who never receives it, between the innovation that works and the reimbursement system that decides whether anyone can afford to deliver it.

Hosted by Kendra Allen, Dr. John Hsu, and William Pedranti, the show brings together a behavioral health revenue strategist, an addiction medicine physician, and a biotech entrepreneur to go inside the clinical, operational, and commercial realities of addiction recovery, medication adherence, opioid use disorder (OUD), and behavioral health. Three different vantage points on the same broken system. Honest about what fails, specific about why, and direct about what a real fix requires.

Topics include: MOUD and MAT clinic operations, medication-assisted treatment adherence, behavioral health reimbursement, opioid use disorder treatment, payer contracting, DEA compliance, FFS-to-value-based care transitions, and the patient adherence gap in controlled substance prescribing.

The Saving Dose is for investors evaluating the addiction recovery and behavioral health infrastructure market. For clinic operators and executives running opioid treatment programs, MOUD practices, and behavioral health facilities. For clinicians in addiction medicine and pain management. For payers and administrators navigating the cost and risk of behavioral health coverage.

New episodes every two weeks. Available on Spotify, Apple Podcasts, YouTube, and wherever you listen.


© 2026 The Saving Dose
Economics Hygiene & Healthy Living Personal Finance Physical Illness & Disease
Episodes
  • The Business of Opioid Treatment | The Saving Dose Ep. 04
    Jun 23 2026

    In the fourth episode of The Saving Dose, William Pedranti and Kendra Allen continue their conversation on the operational reality inside opioid treatment programs and get into the part of addiction recovery that almost nobody in the industry talks about publicly: what happens after the patient walks out the door, why most of them do not come back, and why the system was never designed to know the difference.

    This episode covers the economics of running an addiction treatment practice, why alcohol addiction is in many ways harder to treat than opioid addiction, how the shame and guilt cycle quietly destroys the clinical relationship, and what one text message from a counselor named Ashley revealed about how close patients can be to relapse without anyone knowing.

    In this episode:

    Why money is the single biggest barrier to addiction treatment in America, and why insurance coverage gaps mean that many people who need care most are the least able to access it.

    Why alcohol addiction may be harder to treat than opioid addiction, and what social acceptability has to do with it.

    The shame and guilt cycle: why patients who relapse between visits almost never tell their provider the truth, why that silence is a predictable system failure rather than a character flaw, and what a story about poppy seed muffins reveals about how broken the feedback loop is.

    What opioid treatment programs are actually up against: staffing shortages, burnout, Medicaid reimbursement pressure, patient churn, and a geography problem that puts clinics hours away from the patients who need them most.

    Alumni programs: what they are, why they matter, and why the story of Ashley texting a patient she had not spoken to in a year captures exactly what the gap between visits actually costs.

    How the addiction census grows in economic downturns, why designer drugs and animal tranquilizers are creating new crisis points in cities like Seattle, and what Kendra means when she says we are here to help the desperate.

    Where opioid treatment programs are headed, what the industry is trying to embrace, and why the providers who stay in this space are there for reasons that have nothing to do with the money.

    William's personal story: picking up a close friend's brother from a sober living facility after thirty days, and what it means when someone says recovery is sometimes day to day and sometimes minute to minute.

    About the Hosts

    John Hsu, MD is the Founder and CEO of iPill and a practicing anesthesiologist with 25 years in pain management and addiction medicine. He has taken multiple products through FDA approval and commercial launch. Connect with John: https://www.linkedin.com/in/john-hsu-md-300a8b2a/

    William Pedranti is the COO of iPill, a Georgetown Law graduate, and co-founder of PENG Life Science Ventures. He has taken a biotech company from founding through FDA approval, commercial launch, and exit. Connect with William: https://www.linkedin.com/in/williampedranti/

    Kendra Allen is the CRO of iPill with 20 years in behavioral health revenue strategy, payer contracting, and regulatory navigation. She founded and exited a national healthcare consulting firm. Connect with Kendra: https://www.linkedin.com/in/kendra-allen-cro/

    Website: thesavingdose.com

    Disclaimer: This podcast is for educational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before making any treatment decisions.

    #OpioidCrisis #AddictionRecovery #OpioidUseDisorder #MedicationAdherence #MOUD #BehavioralHealth #AddictionMedicine #OpioidTreatment #SubstanceUseDisorder #HealthcarePodcast #TheSavingDose #RecoveryPodcast #MentalHealth #PublicHealth #PatientRetention #MAT #AlcoholAddiction #OTPChallenges #PatientChurn #AddictionTreatment

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    38 mins
  • Inside the Black Box of Addiction Treatment | The Saving Dose Ep. 03
    Jun 9 2026

    In the third episode of The Saving Dose, William Pedranti sits down with Kendra Allen to map the full continuum of addiction treatment in America and go inside the operational reality of the clinics trying to deliver it. This is not a conversation about clinical failure. It is a conversation about what happens in the seven days between appointments, why most practices have no visibility into that window, and why that invisibility is where most recoveries end.

    This episode covers the levels of care most families do not know exist until they are desperate, what medication-assisted treatment actually is and why the stigma around it is costing lives, how opioid treatment programs are bleeding patients they cannot afford to lose, and what Kendra calls the black box: the gap between the clinic visit and the outcome where providers are flying blind and patients are on their own.

    In this episode:

    What you can do when a loved one needs addiction treatment, why calling your insurance company may not be the right first step, and how to potentially navigate a system that was not designed to be navigated by someone in crisis.

    The full continuum of care from detox through residential to partial hospitalization, intensive outpatient, and MAT: what each level means, what it may cost, and what could drive the decision between them.

    Why medication-assisted treatment may not be giving patients a synthetic high, where the stigma around MAT can come from, and what that stigma may do to the patients who need it most.

    The shame cycle: some reasons why patients who relapse between visits do not tell their providers the truth, what that dishonesty can cost the clinical relationship, and why it may be a predictable system failure rather than a character flaw.

    What it looks like inside a clinic when a patient walks in with a dirty drug test and a story about poppy seed muffins, and what a provider is supposed to do with that.

    Why the seven to fourteen days of medication a patient takes home can be one of the highest-risk windows in recovery, and what can happen when that medication exists in a household where someone else is also struggling.

    Outcomes happen between visits. What Kendra means by that, what her definition of the black box actually is, and why closing it can be the central operational and clinical challenge facing opioid treatment programs in America.

    Why patient churn is not a marketing problem or a clinical problem but an infrastructure problem.

    About the Hosts

    John Hsu, MD is the Founder and CEO of iPill and a practicing anesthesiologist with 25 years in pain management and addiction medicine. He has taken multiple products through FDA approval and commercial launch.

    Connect with John: https://www.linkedin.com/in/john-hsu-md-300a8b2a/

    William Pedranti is the COO of iPill, a Georgetown Law graduate, and co-founder of PENG Life Science Ventures. He has taken a biotech company from founding through FDA approval, commercial launch, and exit.

    Connect with William: https://www.linkedin.com/in/williampedranti/

    Kendra Allen is the CRO of iPill with 20 years in behavioral health revenue strategy, payer contracting, and regulatory navigation. She founded and exited a national healthcare consulting firm.

    Connect with Kendra: https://www.linkedin.com/in/kendra-allen-cro/

    Website: thesavingdose.com

    This podcast is for educational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before making any treatment decisions.

    #OpioidCrisis #AddictionRecovery #OpioidUseDisorder #MedicationAdherence #MOUD #BehavioralHealth #AddictionMedicine #OpioidTreatment #SubstanceUseDisorder #HealthcarePodcast #TheSavingDose #RecoveryPodcast #MentalHealth #PublicHealth #PatientRetention #MAT #ChronicPain

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    39 mins
  • Why Doctors Are Afraid to Prescribe Pain Medication | The Saving Dose Ep. 02
    May 27 2026

    In the second episode of The Saving Dose, John Hsu MD and William Pedranti go deep into the most dangerous misconceptions driving the opioid epidemic, why physicians are afraid to prescribe, what the difference between dependency and addiction actually means clinically, and why America is in its fourth decade of a crisis that has a known solution most patients never receive.

    This episode covers the clinical realities most pain physicians will not say publicly, the myths inside the healthcare system that are directly causing patient harm, and what it would actually take to close the gap between the treatments that exist and the patients who need them.

    In this episode:

    Why over 90% of pain physicians John knows personally are afraid to prescribe opioids, and what that fear is doing to patients in legitimate pain.

    The difference between opioid dependency and opioid use disorder, why the healthcare system keeps confusing the two, and why that confusion is costing lives.

    What happened in pain medicine clinics after the 2016 CDC guidelines, the term that emerged in physician circles, and what it tells us about the consequences of policy without infrastructure.

    Why a cancer patient on opioids for years is not an addict, and what happens when their medication is stopped without a proper taper.

    The multimodal pain therapy approach John was using in 1999 that colleagues thought was acupuncture from China, and why Medicare took 30 years to catch up.

    What happens when an OUD patient goes into surgery and their anesthesiologist does not know how to manage their medications, and why this scenario is more common than anyone admits.

    88% of opioid overdoses today are from illicit fentanyl, not prescription medications, and what that means for how we are treating the wrong problem.

    48 million Americans living with addiction, 5,000 board-certified addiction medicine physicians, and what that ratio says about why we are still in the fourth decade of this epidemic.

    Why the medications that reduce overdose risk by more than 50% exist, and why only 25% of the people who need them are receiving them consistently.

    About the Hosts

    John Hsu, MD is the Founder and CEO of iPill and a practicing anesthesiologist with 25 years in pain management and addiction medicine. He has taken multiple products through FDA approval and commercial launch. Connect with John: https://www.linkedin.com/in/john-hsu-md-300a8b2a/

    William Pedranti is the COO of iPill, a Georgetown Law graduate, and co-founder of PENG Life Science Ventures. He has taken a biotech company from founding through FDA approval, commercial launch, and exit. Connect with William: https://www.linkedin.com/in/williampedranti/

    Kendra Allen is the CRO of iPill with 20 years in behavioral health revenue strategy, payer contracting, and regulatory navigation. She founded and exited a national healthcare consulting firm. Connect with Kendra: https://www.linkedin.com/in/kendra-allen-cro/

    Website: thesavingdose.com

    Disclaimer: This podcast is for educational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before making any treatment decisions.

    #OpioidCrisis #AddictionRecovery #OpioidUseDisorder #MedicationAdherence #PainManagement #MOUD #BehavioralHealth #AddictionMedicine #SubstanceUseDisorder #HealthcarePodcast #TheSavingDose #RecoveryPodcast #OpioidTreatment #ChronicPain #PublicHealth #DrugPolicy #FentanylCrisis #OpioidEpidemic

    Show More Show Less
    35 mins
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