This episode does a deep dive into a study by Northwestern University researchers who examineed how extended overnight fasting (EOF), specifically ending meals at least three hours before sleep, impacts the health of middle-aged and older adults.

Grimaldi D, Reid KJ, Abbott SM, Knutson KL, Zee PC. Sleep-aligned Extended Overnight Fasting Improves Nighttime and Daytime Cardiometabolic Function. Arterioscler Thromb Vasc Biol. 2026;46(4):e323355. doi:10.1161/ATVBAHA.125.323355 [1, 2].

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This episode dissects the findings from the DO-HEALTH trial, a large-scale clinical study examining how vitamin D, omega-3, and exercise influence the biological aging of older adults.

Bischoff-Ferrari HA, Gängler S, Wieczorek M, et al. Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial. Nature Aging. Published online February 3, 2025. doi:10.1038/s43587-024-00793-y

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This episode dissects a systematic review and meta-analysis that evaluates the impact of exercise training on five key blood lipid markers to assist in the management of dyslipidemia.

Smart NA, Downes D, van der Touw T, et al. The effect of exercise training on blood lipids: a systematic review and meta-analysis. Sports Med. 2025;55:67-78. doi:10.1007/s40279-024-02115-z

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This episode does a deep dive into a 2026 study that investigates whether meat consumption influences cognitive decline and dementia risk based on a person's APOE genetic profile.

Norgren J, Carballo-Casla A, Grande G, Börjesson-Hanson A, Xu H, Eriksdotter M, et al. Meat consumption and cognitive health by APOE genotype. JAMA Netw Open. 2026;9(3):e266489. doi:10.1001/jamanetworkopen.2026.6489

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This episode dissects a systematic review and meta-analysis that investigates how physical activity affects inhibitory control in adults diagnosed with ADHD.

Yang Y, Wu CH, Sun L, Zhang TR, Luo J. The impact of physical activity on inhibitory control of adult ADHD: a systematic review and meta-analysis. J Glob Health. 2025;15:04025.

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This episode dissects a study that examines how psychological factors, specifically pain-related fear and catastrophizing, influence recovery in patients with rotator cuff tendinopathy during an 8-week exercise program. Researchers tracked 64 participants to observe if their beliefs about movement and pain changed alongside improvements in shoulder disability.

Mears C, Heindel MD, Abeles R, Vila Dieguez O, Beneciuk JM, Michener LA. Changes in pain-related fear predict shoulder disability in rotator cuff tendinopathy with resistance exercise. *J Orthop Sports Phys Ther*. Published online 2026. doi:10.2519/jospt.2026.13563

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This episode dissects a network meta-analysis that evaluates the effectiveness of various non-surgical interventions for children diagnosed with pediatric flexible flatfoot. Researchers categorized treatments into active exercise-based physical therapy, such as neuromuscular electrical stimulation (NMES) and corrective exercises, and passive orthotic interventions, including talus control insoles and corrective shoes.

Lin LY, Lin AC, Lai PC, Fang CJ, Tu YK, Huang MT, et al. Effects of non-surgical interventions on standing posture and pain in children with flexible flatfoot: a network meta-analysis of randomized controlled trials. Phys Ther. 2026;106(5):pzag033. doi:10.1093/ptj/pzag033

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This episode does a deep dive into a systematic review that examines the safety of creatine monohydrate supplementation among adolescents and physically active youth. By analyzing five studies published between 2015 and 2025, researchers evaluated the supplement's impact on renal function, liver health, and cardiometabolic markers.

Rubinchuk A, Dulkoski Z, Persaud NA, Wallen M. Evaluating the Safety of Creatine Monohydrate in Adolescents: A Systematic Review of Renal, Hepatic, and Cardiometabolic Outcomes. Cureus. 2026;18(4):e106808. doi:10.7759/cureus.106808

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